Rules for priming and inhibition of glycosaminoglycan biosynthesis; probing the β4GalT7 active site-Reference-Cited by-同舟云学术

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Rules for priming and inhibition of glycosaminoglycan biosynthesis; probing the β4GalT7 active site

Published:2014 Issue:9 Volume:5 Page:3501-3508
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Siegbahn Anna¹²³⁴,Manner Sophie¹²³⁴,Persson Andrea¹²³⁴⁵,Tykesson Emil⁵³⁴,Holmqvist Karin¹²³⁴,Ochocinska Agata¹²³⁴,Rönnols Jerk⁶⁷⁸⁹,Sundin Anders¹²³⁴,Mani Katrin⁵³⁴,Westergren-Thorsson Gunilla⁵³⁴,Widmalm Göran⁶⁷⁸⁹,Ellervik Ulf¹²³⁴

Affiliation:

1. Centre for Analysis and Synthesis

2. Centre for Chemistry and Chemical Engineering

3. Lund University

4. SE-221 00 Lund, Sweden

5. Department of Experimental Medical Science

6. Department of Organic Chemistry

7. Arrhenius Laboratory

8. Stockholm University

9. SE-106 91 Stockholm, Sweden

Abstract

Xylose is the optimal substrate for β4GalT7, an essential enzyme in GAG biosynthesis, but analogs act as effective inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC01244E

Reference42 articles.

1. Therapeutic value of glycosaminoglycans in cancer

2. The sweet and sour of cancer: glycans as novel therapeutic targets

3. Roles of heparan-sulphate glycosaminoglycans in cancer

4. Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis

5. Molecular Cloning and Expression of Human UDP-d-Xylose:Proteoglycan Core Protein β-d-Xylosyltransferase and its First Isoform XT-II

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1. Primary Structure of Glycans by NMR Spectroscopy;Chemical Reviews;2023-01-09

2. Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations;Bioconjugate Chemistry;2021-11-16

3. Assays for Evaluation of Substrates for and of β-1,4-Galactosyltransferase 7;Methods in Molecular Biology;2021-10-10

4. Conformation-Controlled Hydrogen-Bond-Mediated Aglycone Delivery Method for α-Xylosylation;The Journal of Organic Chemistry;2021-07-22

5. Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose–Xylose Disaccharide from the Proteoglycan Linkage Region;Organic Letters;2021-02-12

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