Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies-Reference-Cited by-同舟云学术

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

Published:2018 Issue:3 Volume:9 Page:562-575
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Poongavanam Vasanthanathan¹²³⁴⁵^ORCID,Corona Angela⁶⁷⁸^ORCID,Steinmann Casper¹²³⁴⁵^ORCID,Scipione Luigi⁹¹⁰¹¹¹²⁸^ORCID,Grandi Nicole⁶⁷⁸^ORCID,Pandolfi Fabiana⁹¹⁰¹¹¹²⁸^ORCID,Di Santo Roberto⁹¹⁰¹¹¹²⁸^ORCID,Costi Roberta⁹¹⁰¹¹¹²⁸^ORCID,Esposito Francesca⁶⁷⁸^ORCID,Tramontano Enzo⁶⁷⁸¹³¹⁴^ORCID,Kongsted Jacob¹²³⁴⁵^ORCID

Affiliation:

1. Department of Physics

2. Chemistry and Pharmacy

3. University of Southern Denmark

4. DK-5230 Odense M

5. Denmark

6. Department of Life and Environmental Sciences

7. University of Cagliari

8. Italy

9. Dipartimento di Chimica e Tecnologie del Farmaco

10. Istituto Pasteur-Fondazione Cenci Bolognetti

11. “Sapienza” Università di Roma

12. Roma

13. Istituto di Ricerca Genetica e Biomedica

14. Consiglio Nazionale delle Ricerche (CNR)

Abstract

In silico methods identified a new class of inhibitors for HIV-1 RT RNase H and magnesium complexation study reveals the binding mode of these compounds.

Funder

MIUR

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C7MD00600D

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