“Sweet tooth”-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy

Author:

Ding Ning12345ORCID,Xu Shengjun67894,Zheng Sheng12345,Ye Qianwei67894,Xu Li10114,Ling Sunbin67894,Xie Shanshan12813144,Chen Wenwen12345,Zhang Zizhen12345,Xue Meng12345,Lin Zhenghua12345,Xu Xiao67894,Wang Liangjing12345ORCID

Affiliation:

1. Department of Gastroenterology

2. the Second Affiliated Hospital of Zhejiang University School of Medicine

3. Hangzhou 310020

4. China

5. Institution of Gastroenterology

6. Department of Hepatobiliary and Pancreatic Surgery

7. Affiliated Hangzhou First People's Hospital

8. Zhejiang University School of Medicine

9. Hangzhou 310006

10. NHC Key Laboratory of Combined Multi-organ Transplantation

11. Hangzhou 310003

12. The Children's Hospital

13. National Clinical Research Center for Child Health

14. Hangzhou 310052

Abstract

Motivated by the overexpression of GLUT1 in gastric cancer, a targeted SN38 prodrug delivery nanoplatform was constructed and exhibited potent antitumor efficiency, which brought a new insight to the design of nanomedicine against cancer.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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