Reductive aminations by imine reductases: from milligrams to tons-Reference-Cited by-同舟云学术

Reductive aminations by imine reductases: from milligrams to tons

Published:2022 Issue:17 Volume:13 Page:4697-4713
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Gilio Amelia K.¹,Thorpe Thomas W.²,Turner Nicholas²^ORCID,Grogan Gideon¹^ORCID

Affiliation:

1. Department of Chemistry, University of York, Heslington, York YO10 5DD, UK

2. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK

Abstract

IRED-catalyzed reductive aminations have progressed from mg to ton scale, through advances in enzyme discovery, protein engineering and process biocatalysis.

Funder

Pfizer

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00124A

Reference80 articles.

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3. Reductive Amination in the Synthesis of Pharmaceuticals

4. Enantioselective Organocatalytic Reductive Amination

5. Catalytic Asymmetric Reductive Amination of α-Branched Ketones

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