Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases

Published:2024 Issue:3 Volume:15 Page:963-980
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Ţînţaş Mihaela-Liliana¹^ORCID,Peauger Ludovic²^ORCID,Barré Anaïs¹,Papamicaël Cyril¹^ORCID,Besson Thierry¹^ORCID,Sopkovà-de Oliveira Santos Jana³,Gembus Vincent²,Levacher Vincent¹

Affiliation:

1. INSA Rouen Normandie, Univ Rouen Normandie, CNRS, COBRA UMR 6014, Normandie Univ, INC3M FR 3038, F-76000 Rouen, France

2. VFP Therapies, 15 rue François Couperin, 76000 Rouen, France

3. UNICAEN, CERMN (Centre d'Etudes et de Recherche sur le Médicament de Normandie), Normandie Univ., Bd Becquerel, F-14032 Caen, France

Abstract

Promising multitargets ligands in Alzheimer's disease: sequential BuChE and DYRK1A/CLK1 kinases inhibition.

Funder

Université de Rouen

Centre National de la Recherche Scientifique

European Regional Development Fund

XL-Chem Graduate School of Research

Région Normandie

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00708A

Reference54 articles.

1. Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

2. The neuropathological diagnosis of Alzheimer’s disease

3. Neuropathological Alterations in Alzheimer Disease

4. Alzheimer's disease drug development pipeline: 2022

5. Lecanemab in Early Alzheimer’s Disease

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP