An umpolung strategy for chemoselective metal-free [4 + 2] annulation of azlactones: access to tetrahydro-β-carbolin 1,3-diketone frameworks-Reference-Cited by-同舟云学术

An umpolung strategy for chemoselective metal-free [4 + 2] annulation of azlactones: access to tetrahydro-β-carbolin 1,3-diketone frameworks

Published:2024 Issue:3 Volume:11 Page:822-829
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Meng¹,Zheng Ze-Hong¹,Chen Mu-Qiu¹,Zhan Gu¹^ORCID,Wang Jie¹,Yang Qian-Qian¹^ORCID,Huang Wei¹^ORCID

Affiliation:

1. State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

Abstract

A range of tetrahydro-β-carbolin 1,3-diketones can be efficiently synthesized through effective [4 + 2] annulation involving azlactones and indole-2-amides. This method utilizes the umpolung strategy and exhibits excellent compatibility.

Funder

National Natural Science Foundation of China

Chengdu University of Traditional Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01184D

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