Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Brønsted acid

Author:

Li Jianjun12345,Fu Yiwei12345,Qin Cong12345,Yu Yang12345,Li Hao12345ORCID,Wang Wei12345ORCID

Affiliation:

1. State Key Laboratory of Bioengineering Reactor

2. Shanghai Key Laboratory of New Drug Design

3. and School of Pharmacy

4. East China University of Science and Technology

5. Shanghai 200237

Abstract

A mild and efficient asymmetric cyclization reaction catalyzed by chiral Brønsted acids has been developed for the synthesis of chiral isoquinolinonaphthyridines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference62 articles.

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2. D. S. Bhakuni and S.Jain, in The Alkaloids: Chemistry and Pharmacology, ed. A. Brossi, Academic Press, New York, 1986, vol. 28, p. 95

3. Structural Analyses of Metabolites of Phenolic 1-Benzyltetrahydroisoquinolines in Plant Cell Cultures by LC/NMR, LC/MS, and LC/CD

4. M. Hesse , Alkaloids: Nature's Curse or Blessing, Wiley-VCH, Weinheim, Chichester, UK, 2002

5. Berberine Synergy with Amphotericin B against Disseminated Candidiasis in Mice

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