Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level-Reference-Cited by-同舟云学术

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

Published:2020 Issue:27 Volume:12 Page:14708-14723
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Chighizola M.¹²³⁴,Previdi A.¹²³⁴^ORCID,Dini T.¹²³⁴,Piazzoni C.¹²³⁴,Lenardi C.¹²³⁴,Milani P.¹²³⁴,Schulte C.¹²³⁴^ORCID,Podestà A.¹²³⁴^ORCID

Affiliation:

1. C.I.Ma.I.Na. and Dipartimento di Fisica “Aldo Pontremoli”

2. Università degli Studi di Milano

3. 20133 Milan

4. Italy

Abstract

The study shows, by exploiting a novel adhesion force spectroscopy approach, that microenvironmental nanotopography impacts strongly on integrin-mediated cellular mechanosensing, by influencing adhesion site force loading dynamics.

Funder

H2020 Marie Skłodowska-Curie Actions

FP7 Nanosciences, Nanotechnologies, Materials and new Production Technologies

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR01991G

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2. Topotaxis: A New Mechanism of Directed Cell Migration in Topographic ECM Gradients