Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging-Reference-Cited by-同舟云学术

Radiofluorination of a NHC–PF5 adduct: toward new probes for 18F PET imaging

Published:2017 Issue:62 Volume:53 Page:8657-8659
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Vabre Boris¹²³⁴,Chansaenpak Kantapat⁵⁶⁷⁸⁴,Wang Mengzhe⁵⁶⁷⁸⁴,Wang Hui⁵⁶⁷⁸⁴,Li Zibo⁵⁶⁷⁸⁴^ORCID,Gabbaï François P.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Texas A&M University

3. College Station

4. USA

5. Department of Radiology

6. Biomedical Research Imaging Center

7. University of North Carolina

8. Chapel Hill 27599

Abstract

An N-heterocyclic carbene-PF₅ adduct has been radiofluorinated to afford an unusually stable PET probe which has been imaged in vivo.

Funder

Cancer Prevention and Research Institute of Texas

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC04402J

Reference37 articles.

1. Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

2. [18F]-Organotrifluoroborates as Radioprosthetic Groups for PET Imaging: From Design Principles to Preclinical Applications

3. [18F]-Group 13 fluoride derivatives as radiotracers for positron emission tomography

4. Stoichiometric Leverage: Rapid18F-Aryltrifluoroborate Radiosynthesis at High Specific Activity for Click Conjugation

5. A new18F-heteroaryltrifluoroborate radio-prosthetic with greatly enhanced stability that is labelled by18F–19F-isotope exchange in good yield at high specific activity

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