Heparin-mediated electrostatic immobilization of bFGF via functional polymer films for enhanced self-renewal of human neural stem cells-Reference-Cited by-同舟云学术

Heparin-mediated electrostatic immobilization of bFGF via functional polymer films for enhanced self-renewal of human neural stem cells

Published:2021 Issue:8 Volume:9 Page:2084-2091
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Cho Younghak¹²³⁴,Baek Jieung⁵⁶⁷⁷⁸,Lee Eunjung¹²³⁴^ORCID,Im Sung Gap¹²³⁴^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering & KI for NanoCentury

2. Korea Advanced Institute of Science and Technology

3. Daejeon 34141

4. Republic of Korea

5. Department of Chemical and Biomolecular Engineering

6. University of California

7. Berkeley

8. USA

Abstract

A novel copolymer film of pGMA-co-DMAEMA is generated to modulate the electrostatic interaction with heparin, thereby facilitating bFGF immobilization. hNSCs cultured on this surface exhibited enhanced stemness-related properties and neurogenesis.

Funder

Ministry of Trade, Industry and Energy

Ministry of Education, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D0TB02799E

Reference47 articles.

1. Cell replacement therapies for central nervous system disorders

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4. EGF-responsive rat neural stem cells: Molecular follow-up of neuron and astrocyte differentiation in vitro

5. Basic Fibroblast Growth Factor Supports Undifferentiated Human Embryonic Stem Cell Growth Without Conditioned Medium

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