Absolute configuration of the antimalarial erythro-mefloquine – vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative-Reference-Cited by-同舟云学术

Absolute configuration of the antimalarial erythro-mefloquine – vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative

Published:2016 Issue:85 Volume:6 Page:81461-81465
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kohout M.¹²³⁴⁵,Vandenbussche J.⁶⁷⁸⁹,Roller A.¹⁰¹¹¹²¹³,Tůma J.¹²³⁴⁵,Bogaerts J.¹⁴¹⁵¹⁶⁹,Bultinck P.⁶⁷⁸⁹,Herrebout W.¹⁴¹⁵¹⁶⁹,Lindner W.¹⁷¹¹¹²¹³

Affiliation:

1. Department of Organic Chemistry

2. University of Chemistry and Technology Prague

3. Technická 5

4. 166 28 Prague

5. Czech Republic

6. Department of Inorganic and Physical Chemistry

7. Ghent University

8. 9000 Ghent

9. Belgium

10. Institute of Inorganic Chemistry

11. University of Vienna

12. 1090 Vienna

13. Austria

14. Department of Chemistry

15. University of Antwerp

16. 2020 Antwerp

17. Institute of Analytical Chemistry

Abstract

The long-standing discussion of the absolute configuration of erythro-mefloquine is revisited, showcasing the strength of a combination of experimental and calculated vibrational circular dichroism spectroscopy.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA19367F

Reference36 articles.

1. World Health Organization, Malaria fact sheet 94, 2014

2. Adverse neuropsychiatric effects of antimalarial drugs

3. The position of mefloquine as a 21st century malaria chemoprophylaxis

4. Enantioselective high-performance liquid chromatographic determination of (SR)- and (RS)-mefloquine in plasma using N-benzyloxycarbonyl-glycyl-l-proline as chiral counter ion

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