Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor-Reference-Cited by-同舟云学术

Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

Published:2014 Issue:43 Volume:12 Page:8646-8655
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Festa Carmen¹²³,Cassiano Chiara¹⁴⁵,D'Auria Maria Valeria¹²³,Debitus Cécile⁶⁷⁸⁹,Monti Maria Chiara¹⁴⁵,De Marino Simona¹²³

Affiliation:

1. Department of Pharmacy

2. University of Naples “Federico II”

3. 80131 Naples, Italy

4. University of Salerno

5. 84084 Fisciano, Italy

6. Polynesian Research Center on Island Biodiversity

7. IRD

8. UMR241

9. 98713 Papeete, French Polynesia

Abstract

The chemical analysis of two Thorectidae sponges led to the isolation of five new scalarane derivatives along with fifteen known compounds. Their binding capability to TDP-43 was assessed by bio-physical techniques and resulted in the identifications of potent inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01510J

Reference45 articles.

1. Scalarin, a new pentacyclic C-25 terpenoid from the sponge Cacospongia scalaris

2. Scalarane Sesterterpenoids

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4. Cytotoxic Scalarane Sesterterpenes from a Sponge, Hyrtios erecta

5. Three New Scalarane Sesterterpenoids from the Okinawan Sponge Hyrtios erectus

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