Structural characterization of Momordica charantia L. (Cucurbitaceae) oligopeptides and the detection of their capability in non-small cell lung cancer A549 cells: induction of apoptosis

Author:

Dong Jiao12341,Zhang Xianxin1534,Qu Chunxiao6534,Rong Xuedong1534,Liu Jie7894,Qu Yiqing1234

Affiliation:

1. Department of Respiratory Medicine

2. Qilu Hospital of Shandong University

3. Jinan

4. China

5. Shandong Provincial Chest Hospital

6. Department of Pharmacy

7. The Research Center of Allergy & Immunology

8. Shenzhen University School of Medicine

9. Shenzhen

Abstract

MCLO-12 induced apoptosis by up-regulating the ROS, activating the caspases expressions, suppressing the Trx system and subsequently activating a number of Trx-dependent pathways.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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