Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity-Reference-Cited by-同舟云学术

Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity

Published:2017 Issue:53 Volume:53 Page:7234-7237
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Bateman L. A.¹²³³⁴,Nguyen T. B.⁵⁶³⁴,Roberts A. M.¹²³³⁴,Miyamoto D. K.¹²³³⁴,Ku W.-M.¹²³³⁴,Huffman T. R.¹²³³⁴,Petri Y.¹²³³⁴,Heslin M. J.⁷⁸⁴,Contreras C. M.⁷⁸⁴,Skibola C. F.⁷⁸⁴,Olzmann J. A.⁵⁶³⁴,Nomura D. K.¹²³³⁴^ORCID

Affiliation:

1. Departments of Chemistry and Molecular and Cell Biology

2. University of California

3. Berkeley

4. USA

5. Department of Nutritional Sciences and Toxicology

6. University of California, Berkeley

7. The University of Alabama at Birmingham

8. Birmingham

Abstract

Chemoproteomics-enabled covalent ligand discovery reveals a covalent ligand targeting RTN4 that alters ER morphology and impairs cancer pathogenicity.

Funder

National Cancer Institute

National Institute of General Medical Sciences

American Cancer Society

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC01480E

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1. Chemical genetic approaches to probing cell death

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