An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection-Reference-Cited by-同舟云学术

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An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection

Published:2019 Issue:6 Volume:19 Page:993-1005
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ou Chen-Yin¹²³,Vu Tam⁴⁵⁶²³,Grunwald Jonathan T.¹²³,Toledano Michael⁴⁵⁶²³,Zimak Jan⁴⁵⁶²³,Toosky Melody¹²³,Shen Byron¹²³,Zell Jason A.⁷⁶²³⁸,Gratton Enrico⁹⁶²³¹⁰,Abram Timothy J.¹²³,Zhao Weian⁴⁵⁶²³^ORCID

Affiliation:

1. Velox Biosystems

2. Irvine

3. USA

4. Sue and Bill Gross Stem Cell Research Center

5. Sue & Bill Gross Hall CIRM Institute

6. University of California, Irvine

7. Chao Family Comprehensive Cancer Center

8. Division of Hematology/Oncology

9. Department of Biomedical Engineering

10. Laboratory for Fluorescence Dynamics

Abstract

We present an ultra-sensitive, novel liquid biopsy approach which can uniquely enable detection of CTCs using genetic markers without pre-enrichment.

Funder

National Institute of Allergy and Infectious Diseases

Chao Family Comprehensive Cancer Center

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/LC/C8LC01399C

Reference45 articles.

1. Cancer statistics, 2018

2. Liquid biopsy: monitoring cancer-genetics in the blood

3. Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

4. Current and future perspectives of liquid biopsies in genomics-driven oncology

5. Molecular analysis of circulating tumour cells—biology and biomarkers

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