Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines-Reference-Cited by-同舟云学术

Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines

Published:2017 Issue:10 Volume:8 Page:1993-2002
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Costa Marcília P.¹²³⁴,Feitosa Anderson C. S.⁵⁶⁷⁴,Oliveira Fátima C. E.⁵⁶⁷⁴,Cavalcanti Bruno C.⁵⁶⁷⁴,Dias Gleiston G.⁸⁹¹⁰¹¹⁴,Caetano Ewerton W. S.¹²¹³¹⁴⁴¹³,Sales Francisco A. M.¹²¹³¹⁴⁴¹³,Freire Valder N.¹⁵⁶¹⁶⁴,Di Fiore Stefano¹⁷¹⁸¹⁹,Fischer Rainer¹⁷¹⁸¹⁹²⁰²¹,Ladeira Luiz O.⁸¹⁵¹⁰¹¹⁴,da Silva Júnior Eufrânio N.⁸⁹¹⁰¹¹⁴^ORCID,Pessoa Claudia⁵⁶⁷⁴²²

Affiliation:

1. Pharmacy Course

2. Federal University of Piauí

3. 64049-550 Teresina

4. Brazil

5. Department of Physiology and Pharmacology

6. Federal University of Ceará

7. 60430-270 Fortaleza

8. Institute of Exact Sciences

9. Department of Chemistry

10. Federal University of Minas Gerais

11. Belo Horizonte

12. Department of Secondary School and Teachers College

13. Federal Institute of Ceará

14. 60040-531 Fortaleza

15. Department of Physics

16. 60455-760 Fortaleza

17. Fraunhofer Institute for Molecular Biology and Applied Ecology IME

18. Aachen

19. Germany

20. Institute for Molecular Biotechnology

21. RWTH Aachen University

22. Oswaldo Cruz Foundation (Fiocruz)

Abstract

Nor-β-lapachone-loaded (NβL-loaded) microcapsules were characterized. The NβL-loaded PLGA microcapsules exhibited a pronounced initial burst release. The cytotoxic activity against a set of cancer cell lines was investigated.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00196G

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1. Circulating Endothelial Cells, Endothelial Progenitor Cells, and Endothelial Microparticles in Cancer

2. The Biology of Cancer Stem Cells