Chitosan–saccharide conjugates for eradication of Pseudomonas aeruginosa biofilms

Author:

Sahariah Priyanka1ORCID,Papi Francesco2ORCID,Merz Koi L.2,Sigurjonsson Olafur E.3ORCID,Meyer Rikke Loiuse45ORCID,Nativi Cristina2ORCID

Affiliation:

1. Department of Life and Environmental Sciences, Biomedical Centre, University of Iceland, 101 Reykjavik, Iceland

2. Department of Chemistry, University of Florence, Sesto F.no, Florence, Italy

3. The REModeL Lab, The Blood Bank, Landspitali University Hospital, Snorrabraut 60, 105 Reykjavik, Iceland

4. iNANO, Aarhus University, Gustav Weids Vej 14, 8000 Aarhus C, Denmark

5. Department of Bioscience, Aarhus University, Ny Munkegade 114, 8000 Aarhus C, Denmark

Abstract

The problem of antibiotic resistance has raised serious concerns globally. Herein, we report the synthesis of new chitosan-saccharide conjugates to eradicate Pseudomonas aeruginosa biofilms.

Funder

Háskóli Íslands

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Reference37 articles.

1. W. H.Organization , Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis, Report 9240026436 , World Health Organization , 2017

2. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

3. M. G.Wilson and S.Pandey , Pseudomonas aeruginosa . [Updated 2023 Aug 8]. In StatPearls [Internet], StatPearls Publishing , Treasure Island (FL) , 2024 . Available from: https://www.ncbi.nlm.nih.gov/books/NBK557831/

4. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

5. Antibiotic resistance of bacteria in biofilms

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