Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies-Reference-Cited by-同舟云学术

Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies

Published:2014 Issue:11 Volume:6 Page:6046-6056
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zarschler K.¹²³,Prapainop K.⁴⁵⁶⁷,Mahon E.⁴⁵⁶⁷,Rocks L.⁴⁵⁶⁷,Bramini M.⁴⁵⁶⁷,Kelly P. M.⁴⁵⁶⁷,Stephan H.¹²³,Dawson K. A.⁴⁵⁶⁷

Affiliation:

1. Institute of Radiopharmaceutical Cancer Research

2. Helmholtz-Zentrum Dresden-Rossendorf

3. D-01328 Dresden, Germany

4. Centre For BioNano Interactions (CBNI)

5. School of Chemistry and Chemical Biology

6. University College Dublin

7. Belfield, Ireland

Abstract

Nanoparticles functionalized with single domain antibodies are shown to specifically target the EGF receptor in vitro. We investigate the effects on uptake and specificity when increasing the environmental serum toward more in vivo "realistic" concentrations.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2014/NR/C4NR00595C

Reference66 articles.

1. Nanotechnology: Carrying drugs

2. Cancer nanotechnology: opportunities and challenges

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