Unveiling and tackling guanidinium peptide coupling reagent side reactions towards the development of peptide-drug conjugates
Author:
Affiliation:
1. Section of Organic Chemistry and Biochemistry
2. Department of Chemistry
3. University of Ioannina
4. Ioannina GR-45110
5. Greece
Abstract
Discovery of uncharted guanidinium peptide coupling reagent side reactions during peptide-drug conjugates synthesis.
Funder
Greek State Fellowships Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA06655D
Reference26 articles.
1. Peptide Coupling in the Presence of Highly Hindered Tertiary Amines
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4. Recognition Pliability Is Coupled to Structural Heterogeneity: A Calmodulin Intrinsically Disordered Binding Region Complex
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