Simultaneous quantification of imatinib and CGP74588 in human plasma by liquid chromatography-time of flight mass spectrometry (LC-TOF-MS)-Reference-Cited by-同舟云学术

Simultaneous quantification of imatinib and CGP74588 in human plasma by liquid chromatography-time of flight mass spectrometry (LC-TOF-MS)

Published:2016 Issue:15 Volume:8 Page:3046-3054
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Ubhayasekera S. J. Kumari A.¹²³⁴⁵,Aluthgedara Warunika¹²³⁴⁵,Ek Bo¹²³⁴⁵,Bergquist Jonas¹²³⁴⁵

Affiliation:

1. Department of Chemistry – Biomedical Center

2. Analytical Chemistry and Science for Life Laboratory

3. Uppsala University

4. Uppsala

5. Sweden

Abstract

Imatinib mesylate is widely used for the treatment of different types of cancer, such as chronic myelogenous leukemia and gastrointestinal stromal tumors.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/AY/C5AY02807H

Reference25 articles.

1. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study

2. The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib

3. Quantification of the anti-leukemia drug STI571 (Gleevec™) and its metabolite (CGP 74588) in monkey plasma using a semi-automated solid phase extraction procedure and liquid chromatography-tandem mass spectrometry

4. Absolute Bioavailability of Imatinib (Glivec®) Orally versus Intravenous Infusion

5. Clinical Pharmacokinetics of Imatinib

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