Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction

Author:

Torrieri Giulia12345ORCID,Fontana Flavia12345,Figueiredo Patrícia12345,Liu Zehua12345,Ferreira Mónica P. A.12345,Talman Virpi16347,Martins João P.12345,Fusciello Manlio18347,Moslova Karina94710,Teesalu Tambet1112131415,Cerullo Vincenzo18347,Hirvonen Jouni12345,Ruskoaho Heikki16347,Balasubramanian Vimalkumar12345,Santos Hélder A.12345ORCID

Affiliation:

1. Drug Research Program

2. Division of Pharmaceutical Chemistry and Technology

3. Faculty of Pharmacy

4. University of Helsinki

5. FI-00014 Helsinki

6. Division of Pharmacology and Pharmacotherapy

7. Helsinki

8. Division of Pharmaceutical Biosciences

9. Department of Chemistry

10. Finland

11. Laboratory of Cancer Biology

12. Institute of Biomedicine and Translational Medicine

13. Centre of Excellence for Translational Medicine

14. University of Tartu

15. Tartu

Abstract

Fabrication of a dual-peptide functionalized acetalated dextran based nanosystem able to exploit macrophage recruitment occurring during myocardial infarction.

Funder

Helsingin Yliopisto

Sigrid Juséliuksen Säätiö

Terveyden Tutkimuksen Toimikunta

European Regional Development Fund

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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