A novel “on–off–on” fluorescence assay for the discriminative detection of Cu(ii) and l-cysteine based on red-emissive Si-CDs and cellular imaging applications

Author:

Zan Minghui12345ORCID,Li Cong12345,Zhu Daoming12345ORCID,Rao Lang12345,Meng Qian-Fang12345,Chen Bei12345ORCID,Xie Wei12345,Qie Xingwang67895,Li Li67895ORCID,Zeng Xiaojiao1011345,Li Yirong1011345,Dong Wen-fei67895ORCID,Liu Wei12345ORCID

Affiliation:

1. Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education

2. School of Physics and Technology

3. Wuhan University

4. Wuhan

5. China

6. CAS Key Laboratory of Bio-Medical Diagnostics

7. Suzhou Institute of Biomedical Engineering and Technology

8. Chinese Academy of Sciences

9. Suzhou

10. Department of Clinical Laboratory

11. Zhongnan Hospital

Abstract

Copper ions (Cu2+) and l-cysteine (l-Cys) in the human body always play critical roles in various physiological processes, while abnormal Cu2+ and l-Cys concentrations in the biological system lead to many diseases.

Funder

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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