Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone-Reference-Cited by-同舟云学术

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone

Published:2017 Issue:6 Volume:8 Page:4644-4653
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Podewin Tom¹²³⁴^ORCID,Broichhagen Johannes¹²³⁴^ORCID,Frost Christina⁵⁶⁷⁴^ORCID,Groneberg Dieter⁸⁹¹⁰⁴^ORCID,Ast Julia¹¹¹²¹³¹⁴¹⁵^ORCID,Meyer-Berg Helena¹²³⁴^ORCID,Fine Nicholas H. F.¹¹¹²¹³¹⁴¹⁵^ORCID,Friebe Andreas⁸⁹¹⁰⁴^ORCID,Zacharias Martin⁵⁶⁷⁴^ORCID,Hodson David J.¹¹¹²¹³¹⁴¹⁵^ORCID,Trauner Dirk¹²³⁴^ORCID,Hoffmann-Röder Anja¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Center for Integrated Protein Science

2. LMU Munich

3. 81377 Munich

4. Germany

5. Department of Physics

6. Technical University of Munich

7. 85748 Garching

8. Julius-Maximilian-University Würzburg

9. Institute of Physiology

10. 97070 Würzburg

11. Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE)

12. University of Birmingham

13. UK

14. Centre for Endocrinology

15. Diabetes and Metabolism

Abstract

The photoswitchable peptidomimetic hormone TOP271 allows the precise optical control of cGMP generation via the receptor-linked enzyme NPR-A in explanted aortic rings and islets of Langerhans.

Funder

European Research Council

Studienstiftung des Deutschen Volkes

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC05044A

Reference76 articles.

1. Optogenetics