Synthetic single and double aza-scorpiand macrocycles acting as inhibitors of the antioxidant enzymes iron superoxide dismutase and trypanothione reductase in Trypanosoma cruzi with promising results in a murine model-Reference-Cited by-同舟云学术

Synthetic single and double aza-scorpiand macrocycles acting as inhibitors of the antioxidant enzymes iron superoxide dismutase and trypanothione reductase in Trypanosoma cruzi with promising results in a murine model

Published:2014 Issue:110 Volume:4 Page:65108-65120
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Olmo F.¹²³⁴,Clares M. P.⁵⁶⁷⁸,Marín C.¹²³⁴,González J.⁵⁶⁷⁸,Inclán M.⁵⁶⁷⁸,Soriano C.⁹⁷⁸,Urbanová K.¹²³⁴,Tejero R.¹⁰⁷⁸,Rosales M. J.¹²³⁴,Krauth-Siegel R. L.¹¹¹²,Sánchez-Moreno M.¹²³⁴,García-España E.⁵⁶⁷⁸

Affiliation:

1. Departamento de Parasitología

2. Instituto de Investigación Biosanitaria ibs. Granada

3. Universidad de Granada

4. Granada, Spain

5. Instituto de Ciencia Molecular

6. Departamento de Química Inorgánica

7. Universidad de Valencia

8. Valencia, Spain

9. Departamento de Química Orgánica

10. Departamento de Química Física

11. Biochemie-Zentrum der Universität Heidelberg

12. 69120 Heidelberg, Germany

Abstract

Synthetic scorpiand-like azamacrocycles selectively inhibit SOD and TR enzymes of Trypanosoma cruzi in mice causing death of the parasites and increasing the mouse survival rate after infection and treatment.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA09866H

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