Ultrasensitive carbohydrate-peptide SPR imaging microarray for diagnosing IgE mediated peanut allergy
Author:
Affiliation:
1. Department of Chemistry
2. University of Connecticut
3. Storrs, USA
4. Department of Molecular & Cell Biology
5. Institute of Materials Science
Abstract
The first peptide-carbohydrate SPR imaging immunoarray aimed at diagnosing severity of peanut allergies is reported. The SPRi chip features a peptide epitope of peanut protein allergen Ara h2, a β-xylosyl glycoside, and anti-IgE antibody to achieve epitope-specific detection of human allergen IgEs at sub-attomol levels.
Funder
National Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/AN/C4AN01544D
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