A pre-column derivatization method allowing quantitative metabolite profiling of carboxyl and phenolic hydroxyl group containing pharmaceuticals in human plasma via liquid chromatography-inductively coupled plasma-tandem mass spectrometry (LC-ICP-MS/MS)
Author:
Affiliation:
1. Ghent University
2. Department of Chemistry
3. Atomic and Mass Spectrometry Research Group (A&MS)
4. 9000 Ghent
5. Belgium
6. Pharmacokinetics, Dynamics & Metabolism
7. Janssen R&D
8. Department of Organic and Macromolecular Chemistry
Abstract
Novel analytical strategies for investigating drug ADME (absorption, distribution, metabolism and excretion).
Funder
China Scholarship Council
Universiteit Gent
Publisher
Royal Society of Chemistry (RSC)
Subject
Spectroscopy,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/JA/C7JA00385D
Reference42 articles.
1. The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies
2. Identification and Quantification of Metabolites of the Fungicide Tebuconazole in Human Urine
3. Identification and quantification of the atypical metabolite ornithine-lactam in human plasma by liquid chromatography–tandem mass spectrometry (LC–MS/MS)
4. Metabolite identification and quantitation in LC-MS/MS-based metabolomics
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