Characterization of degradation products of regorafenib by LC-QTOF-MS and NMR spectroscopy: investigation of rearrangement and odd-electron ion formation during collision-induced dissociations under ESI-MS/MS-Reference-Cited by-同舟云学术

Characterization of degradation products of regorafenib by LC-QTOF-MS and NMR spectroscopy: investigation of rearrangement and odd-electron ion formation during collision-induced dissociations under ESI-MS/MS

Published:2017 Issue:20 Volume:41 Page:12091-12103
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Baira Shandilya Mahamuni¹²³⁴,Srinivasulu Gannoju¹²³⁴,Nimbalkar Rakesh⁵⁶⁴,Garg Prabha⁵⁶⁴^ORCID,Srinivas R.¹²³⁴⁷,Talluri M. V. N. Kumar¹²³⁴^ORCID

Affiliation:

1. Department of Pharmaceutical Analysis

2. National Institute of Pharmaceutical Education & Research

3. Hyderabad

4. India

5. Department of Pharmacoinformatics, National Institute of Pharmaceutical Education & Research

6. Mohali

7. NCMS, CSIR-Indian Institute of Chemical Technology

Abstract

Characterization of degradation products of regorafenib by LC-QTOF-MS and NMR.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NJ/C7NJ01440F

Reference29 articles.

1. Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

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4. Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

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