Detection of UVA/UVC-induced damage of p53 fragment by rolling circle amplification with AIEgens

Author:

Ou Xiaowen12345,Wei Benmei12345,Zhang Zhenyu12345,Zhang Mengshi12345,Zhuang Yuan12345,Gao Pengcheng12345,Lou Xiaoding12345,Xia Fan12345,Tang Ben Zhong6789

Affiliation:

1. Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica

2. Key Laboratory of Material Chemistry for Energy Conversion and Storage

3. Ministry of Education

4. School of Chemistry and Chemical Engineering

5. Huazhong University of Science and Technology

6. Department of Chemistry

7. The Hong Kong University of Science and Technology

8. Kowloon

9. China

Abstract

A new strategy combining the rolling circle amplification and the aggregation-induced emission molecule is achieved to differentiate damaged and undamaged p53 fragments.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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