An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies-Reference-Cited by-同舟云学术

An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

Published:2015 Issue:44 Volume:51 Page:9169-9172
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gandioso Albert¹²³⁴,Shaili Evyenia⁵⁶⁷⁸,Massaguer Anna⁹¹⁰¹¹⁴,Artigas Gerard¹²³⁴,González-Cantó Alejandro¹²³⁴,Woods Julie A.¹²¹³¹⁴¹⁵⁸,Sadler Peter J.⁵⁶⁷⁸,Marchán Vicente¹²³⁴

Affiliation:

1. Departament de Química Orgànica and IBUB

2. Universitat de Barcelona

3. Barcelona

4. Spain

5. Department of Chemistry

6. University of Warwick

7. Warwick

8. UK

9. Departament de Biologia

10. Universitat de Girona

11. Girona

12. Photobiology Unit

13. Department of Dermatology

14. Ninewells Hospital

15. Dundee

Abstract

A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC03180J

Reference33 articles.

1. From cisplatin to photoreactive Ru complexes: targeting DNA for biomedical applications

2. Potential photoactivated metallopharmaceuticals: from active molecules to supported drugs

3. Photoactivatable metal complexes: from theory to applications in biotechnology and medicine

4. A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light

5. Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts

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