Nanonization of andrographolide by a wet milling method: the effects of vitamin E TPGS and oral bioavailability enhancement-Reference-Cited by-同舟云学术

Nanonization of andrographolide by a wet milling method: the effects of vitamin E TPGS and oral bioavailability enhancement

Published:2016 Issue:103 Volume:6 Page:101404-101414
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Du Ping¹²³⁴⁵,Jiang Qikun¹²³⁴⁵,Yang Rujie¹²³⁴⁵,Liu Cuiru¹²³⁴⁵,Li Yingchao¹²³⁴⁵,Wang Liyuan¹²³⁴⁵,Xue Peng⁶²³⁴⁵,Fu Qiang⁶²³⁴⁵,Zhang Tianhong¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutical Analysis

2. School of Pharmacy

3. Shenyang Pharmaceutical University

4. Shenyang 110016

5. PR China

6. Department of Pharmaceutics

Abstract

Andrographolide (AND) has wide prospects in clinical use, but suffers from the restriction of poor oral bioavailability, due to its low solubility, rapid and extensive metabolism and efflux by P-glycoprotein (P-gp).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA16002F

Reference52 articles.

1. Activity of antibacterial, antiviral, anti-inflammatory in compounds andrographolide salt

2. A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway

3. Targeting of Liposomal Andrographolide toL.donovani-Infected Macrophages in Vivo

4. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata

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