A metal-coordination stabilized small-molecule nanomedicine with high drug-loading capacity and synergistic photochemotherapy for cancer treatment

Author:

Chen Han12,Qu Haijing12,Lu Beike1,Pan Yuqing12,Yang Jiaojiao1,Duan Zhiran12,Wu Jie12,Wang Yanjun13,Wang Chao1,Hu Rong3,Xue Xiangdong12ORCID

Affiliation:

1. Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China

2. National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China

3. Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Centre for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai 200011, China

Abstract

A small-molecule nanomedicine with high drug loading, robust stability, responsive drug release and a synergistic photochemotherapeutic effect has been developed for cancer therapy. Image created with Biorender.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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