Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release

Abstract

Legumain enzyme is a well-conserved lysosomal cysteine protease that is overexpressed in many tumor cells and tumor stromal cells. Herein, we developed a legumain/pH double-sensitive nanosystem for targeted tumor therapy.