Isoxerophilins A and B, two diterpene heterodimers from <i>Isodon xerophilus</i>: structural elucidation and semisynthesis of isoxerophilin analogues-Reference-Cited by-同舟云学术

Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues

Published:2024 Issue:1 Volume:11 Page:37-46
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Dai Jia-Meng¹²,Yan Bing-Chao¹,Kong Ling-Mei¹,Hu Kun¹,Li Xing-Ren¹,Li Xiao-Nian¹,Sun Han-Dong¹^ORCID,Li Yan¹,Puno Pema-Tenzin¹^ORCID

Affiliation:

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Two unprecedented diterpene heterodimers, isoxerophilins A and B (1 and 2), were isolated from Isodon xerophilus. A bioinspired semisynthesis of ten isoxerophilin analogues was accomplished. Compound 12 exhibited obvious latent tumor immunotherapy activity.

Funder

National Natural Science Foundation of China-Yunnan Joint Fund

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Natural Science Foundation of Yunnan Province

National Science Fund for Distinguished Young Scholars

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01679J