2,3-Dihydroquinazolin-4(1<i>H</i>)-ones and quinazolin-4(3<i>H</i>)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation-Reference-Cited by-同舟云学术

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2,3-Dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation

Published:2024 Issue:5 Volume:15 Page:1686-1708
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

O'Brien Nicholas S.¹,Gilbert Jayne²,McCluskey Adam¹^ORCID,Sakoff Jennette A.²

Affiliation:

1. Chemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia

2. Experimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street, Waratah, 2298, NSW, Australia

Abstract

Simple synthesis, binds and inhibits tubulin, and potent broad-spectrum cytotoxicity.

Funder

Australian Research Council

Australian Cancer Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00600J

Reference51 articles.

1. Phenotypic screening in cancer drug discovery — past, present and future

2. Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors

3. Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase

4. Synthesis of the Pitstop family of clathrin inhibitors

5. Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Iodine-promoted sequential C(sp³)–H oxidation and cyclization of aryl methyl ketones with 2-(2-aminophenyl)quinazolin-4(3H)-ones;Organic & Biomolecular Chemistry;2024

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