Effect of hypoxia on the pharmacokinetics and metabolism of zaleplon as a probe of CYP3A1/2 activity-Reference-Cited by-同舟云学术

Effect of hypoxia on the pharmacokinetics and metabolism of zaleplon as a probe of CYP3A1/2 activity

Published:2017 Issue:41 Volume:7 Page:25414-25421
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Gong Wenwen¹²³⁴⁵,Xu Pingxiang¹²³⁴⁵,Guo Shanshan¹²³⁴⁵,Li Xiaorong¹²³⁴⁵,Jin Zengliang¹²³⁴⁵,Zhao Yuming¹²³⁴⁵,Fan Ming⁶³⁴⁷⁸,Xue Ming¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacology

2. Beijing Laboratory for Biomedical Detection Technology and Instrument

3. School of Basic Medical Sciences

4. Capital Medical University

5. Beijing 100069

6. Department of Nerobiology

7. Beijing

8. China

Abstract

The objective of this study was to compare the pharmacokinetics and metabolism of zaleplon (ZAL) in rats under hypoxic and normoxic condition and the effect of hypoxia on the protein expression and activities of the main metabolic enzyme CYP3A1/2.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA03025H

Reference30 articles.

1. Evaluation of the discriminative stimulus effects of the novel sedative-hypnotic CL 284,846

2. Zaleplon

3. Zolpidem

4. Metabolism of Benzodiazepine and Non-Benzodiazepine Anxiolytic-Hypnotic Drugs: an Analytical Point of View

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