Characterization of recombinant human lactoferrin expressed in <i>Komagataella phaffii</i>-Reference-Cited by-同舟云学术

Characterization of recombinant human lactoferrin expressed in Komagataella phaffii

Published:2024 Issue:13 Volume:149 Page:3636-3650
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Lu Xiaoning¹^ORCID,Cummings Chad¹^ORCID,Osuala Udodili A.¹^ORCID,Yennawar Neela H.²^ORCID,Namitz Kevin E. W.²^ORCID,Hellner Brittney¹^ORCID,Besada-Lombana Pamela B.¹^ORCID,Peterson Ross D.¹^ORCID,Clark Anthony J.¹^ORCID

Affiliation:

1. Helaina Inc., 345 Park Avenue South, 5th Floor, New York, NY 10010, USA

2. X-ray Crystallography Core Facility, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA

Abstract

This work presents a thorough characterization of Helaina recombinant human lactoferrin (rhLF, Effera™) expressed in a yeast system at an industrial scale for the first time.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D4AN00333K

Reference73 articles.

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1. 4-week GLP immunotoxicity assessment of lactoferrin alpha produced byKomagataella phaffiiin Sprague Dawley rats;2024-08-19

2. Workshop report: A study roadmap to evaluate the safety of recombinant human lactoferrin expressed in Komagataella phaffii intended as an ingredient in conventional foods – Recommendations of a scientific expert panel;Food and Chemical Toxicology;2024-08

3. A Randomized, Double-Blind, Controlled Trial to Assess the Effects of Lactoferrin at Two Doses vs. Active Control on Immunological and Safety Parameters in Healthy Adults;2024-07-17