Synthesis of 2-amino-9H-chromeno[2,3-d]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide-Reference-Cited by-同舟云学术

Synthesis of 2-amino-9H-chromeno[2,3-d]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide

Published:2024 Issue:5 Volume:14 Page:3158-3162
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tan Jiangtao¹²,He Yifan¹²,Lin Yu¹,Zhong Yuanchen¹,He Shijun¹³,Zuo Jianping¹²,Yang Chunhao¹²^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia, Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. School of Pharmacy, University of Chinese Academy of Sciences, No. 19A YuquanRoad, Beijing 100049, China

3. Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Abstract

A concise and efficient protocol for constructing a chromone fused thiazole scaffold via a copper-promoted cascade reaction was developed. Representative compound c12 showed good anti-inflammatory activity.

Funder

Science and Technology Commission of Shanghai Municipality

State Key Laboratory of Drug Research, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA07209F

Reference36 articles.

1. Chromone: A Valid Scaffold in Medicinal Chemistry

2. Chromones as a privileged scaffold in drug discovery: A review

3. Prenylated chromones and flavonoids from Artocarpus heterophyllus with their potential antiproliferative and anti-inflammatory activities

4. Two chromones with antimicrobial activity from the leaf latex of Aloe monticola Reynolds

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