Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants-Reference-Cited by-同舟云学术

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

Published:2017 Issue:77 Volume:53 Page:10656-10659
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Alexandru-Crivac Cristina N.¹²³⁴⁵,Umeobika Christian¹²³⁴⁵,Leikoski Niina⁶⁷⁸⁹,Jokela Jouni⁶⁷⁸⁹^ORCID,Rickaby Kirstie A.¹²³⁴⁵,Grilo André M.¹²³⁴⁵,Sjö Peter¹⁰¹¹¹²¹³¹⁴^ORCID,Plowright Alleyn T.¹⁰¹⁵¹⁴¹⁶¹⁷,Idress Mohannad¹²³⁴⁵,Siebs Eike¹²³⁴⁵,Nneoyi-Egbe Ada¹²³⁴⁵,Wahlsten Matti⁶⁷⁸⁹^ORCID,Sivonen Kaarina⁶⁷⁸⁹^ORCID,Jaspars Marcel¹²³⁴⁵^ORCID,Trembleau Laurent¹²³⁴⁵^ORCID,Fewer David P.⁶⁷⁸⁹^ORCID,Houssen Wael E.¹²³⁴⁵^ORCID

Affiliation:

1. Marine Biodiscovery Centre

2. Department of Chemistry

3. University of Aberdeen

4. Meston Walk

5. Aberdeen AB24 3UE

6. Microbiology and Biotechnology Division

7. Department of Food and Environmental Sciences

8. University of Helsinki

9. Finland

10. Medicinal Chemistry

11. Respiratory

12. Inflammation & Autoimmunity

13. Innovative Medicines and Early Development Biotech Unit

14. AstraZeneca

15. Cardiovascular and Metabolic Diseases Innovative Medicines and Early Development Biotech Unit

16. Mölndal

17. Sweden

Abstract

The cyanobactin macrocyclase (OscG_mac) has high substrate promiscuity and can be used for making libraries of highly diverse cyclic peptides.

Funder

AstraZeneca

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC05913B

Reference29 articles.

1. Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

2. The exploration of macrocycles for drug discovery — an underexploited structural class

3. Targeting protein−protein interfaces using macrocyclic peptides

4. Tools and rules for macrocycles

5. How proteins bind macrocycles

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