Radiolabeled albumin through S<sub>N</sub>Ar of cysteines as a potential pretargeting theranostic agent-Reference-Cited by-同舟云学术

Radiolabeled albumin through S_NAr of cysteines as a potential pretargeting theranostic agent

Published:2022 Issue:54 Volume:12 Page:35032-35036
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Fischer Niklas H.¹²^ORCID,Lopes van den Broek Sara I.³,Herth Matthias M.³⁴^ORCID,Diness Frederik¹²^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, University of Copenhagen, Universitetsparken 5, Copenhagen 2100, Denmark

2. Department of Science and Environment, Roskilde University, Universitetsparken 1, Roskilde 4000, Denmark

3. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, Copenhagen 2100, Denmark

4. Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark

Abstract

Human serum albumin has been functionalized with a radionuclide by combining SNAr conjugation to Cys34 with CuAAC and inverse-electron demand Diels–Alder reactions demonstrating a promising strategy for generating theranostics by bioconjugation.

Funder

H2020 Marie Skłodowska-Curie Actions

Novo Nordisk Fonden

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA06406E

Reference43 articles.

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3. Breast cancer sentinel lymph node mapping using near infrared guided indocyanine green and indocyanine green–human serum albumin in comparison with gamma emitting radioactive colloid tracer

4. Physiological and Molecular Mechanisms of Lymphocyte Homing

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