A mode of action study of cationic anthraquinone analogs: a new class of highly potent anticancer agents

Author:

Shrestha Jaya P.1234,Subedi Yagya Prasad1234,Chen Liaohai1234,Chang Cheng-Wei Tom1234

Affiliation:

1. Department of Chemistry and Biochemistry

2. Utah State University

3. Logan

4. USA

Abstract

Previously, we reported the synthesis and structure–activity relationship (SAR) study of a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-3-ium salts, which had very potent anti-proliferative activities (low μM to nM GI50) against a broad range of cancer cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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