Facile access to chiral chromanone-2-carboxylic acids enabled by rhodium-catalyzed chemo- and enantioselective hydrogenation

Author:

Nie Zhuang12,Liu Song3ORCID,Wang Tonglin2,Shen Zhanhong2,Nie Huifang2ORCID,Xi Jiayue2,Zhang Dongxu2,Zheng Xiaohui1ORCID,Zhang Shengyong2,Yao Lin2ORCID

Affiliation:

1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Science, Northwest University, Xi’an 710069, P. R. China

2. Department of Medicinal Chemistry and Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi’an, 710032, P. R. China

3. Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, P. R. China

Abstract

Rh-catalyzed highly chemo- and enantioselective hydrogenation of chromone-2-carboxylic acids was first successfully established and an enantio-induction mode was elucidated by DFT calculation.

Funder

National Natural Science Foundation of China

Chongqing Science and Technology Commission

Chongqing University of Arts and Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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