StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin-Reference-Cited by-同舟云学术

StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin

Published:2018 Issue:47 Volume:16 Page:9124-9128
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Xiaozheng¹²³⁴⁵,Kong Dekun¹²³⁴⁵,Huang Tingting¹²³⁴⁵,Deng Zixin¹²³⁴⁵,Lin Shuangjun¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Microbial Metabolism

2. Joint International Laboratory of Metabolic & Developmental Sciences

3. School of Life Sciences & Biotechnology

4. Shanghai Jiao Tong University

5. Shanghai

Abstract

StnK2 is a new Pictet–Spenglerase specifically catalyzing a (1R,3S,4S)-tetrahydro-β-carboline scaffold as the biosynthetic intermediate of the antitumor reagent streptonigrin.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02710B

Reference33 articles.

1. Molecular and crystal structure of streptonigrin

2. Studies Relating to Aziridine Antitumor Antibiotics. Part II. 13C and 1H Nuclear Magnetic Resonance Spectra of Mitomycin C and Structurally Related Streptonigrin

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Engineering a norcoclaurine synthase for one-step synthesis of (S)-1-aryl-tetrahydroisoquinolines;Bioresources and Bioprocessing;2023-03-01

2. A new β-carboline alkaloid from the Streptomyces flocculus CGMCC4.1223 mutant ΔstnK4;Tetrahedron;2023-01

3. Flavoprotein StnP2 Catalyzes the β-Carboline Formation during the Streptonigrin Biosynthesis;ACS Chemical Biology;2022-11-21

4. Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products;Natural Product Reports;2022

5. Recent advances in biocatalysis of nitrogen-containing heterocycles;Biotechnology Advances;2022-01