The kinetic mechanism of Human Thymidine Phosphorylase – a molecular target for cancer drug development-Reference-Cited by-同舟云学术

The kinetic mechanism of Human Thymidine Phosphorylase – a molecular target for cancer drug development

Published:2014 Issue:3 Volume:10 Page:592-604
ISSN:1742-206X
Container-title:Mol. BioSyst.
language:en
Short-container-title:Mol. BioSyst.

Author:

Deves Candida¹²³⁴⁵,Rostirolla Diana Carolina¹²³⁴⁵,Martinelli Leonardo Kras Borges¹²³⁴,Bizarro Cristiano Valim¹²³⁴,Santos Diogenes Santiago¹²³⁴⁵,Basso Luiz Augusto¹²³⁴⁵

Affiliation:

1. Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF)

2. Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)

3. Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)

4. Porto Alegre, Brazil

5. Programa de Pós-Graduação em Medicina e Ciências da Saúde

Abstract

A rapid-equilibrium random bi–bi kinetic mechanism and thermodynamics of binding of substrates and products are described for Human Thymidine Phosphorylase.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MB/C3MB70453J

Reference61 articles.

1. Structural analyses reveal two distinct families of nucleoside phosphorylases

2. Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity

3. Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy

4. Platelet-derived endothelial cell growth factor

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