Potential benefits of egg white hydrolysate in the prevention of Hg-induced dysfunction in adipose tissue

Author:

Rizzetti Danize Aparecida1ORCID,Corrales Patricia2,Uranga-Ocio José Antonio23ORCID,Medina-Gómez Gema2ORCID,Peçanha Franck Maciel1,Vassallo Dalton Valentim4,Miguel Marta5ORCID,Wiggers Giulia Alessandra1ORCID

Affiliation:

1. Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana, Rio Grande do Sul, Brazil

2. Department of Basic Health Sciences, Universidad Rey Juan Carlos, Atenas s/n, Alcorcón, Spain

3. High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut-URJC), Universidad Rey Juan Carlos, Atenas s/n, Alcorcón, Spain

4. Cardiac Electromechanical and Vascular Reactivity Laboratory, Universidade Federal do Espírito Santo, Marechal Campos, 1468, Vitória, Espírito Santo, Brazil

5. Bioactivity and Food Analysis Laboratory, Instituto de Investigación en Ciencias de la Alimentación, Nicolás Cabrera, 9, Campus Universitario de Cantoblanco, Madrid, Spain

Abstract

EWH prevented the morphological and metabolic disorder induced by chronic Hg exposure at low doses, by improving antioxidant defenses, inactivating pro-apoptotic pathways and normalizing the mRNA expression of PPARs and adipokines.

Funder

Agencia Estatal de Investigación

Fundação Estadual de Amparo à Pesquisa do Estado do Espírito Santo

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

European Regional Development Fund

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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