Investigating the mechanotransduction of transient shear stress mediated by Piezo1 ion channel using a 3D printed dynamic gravity pump-Reference-Cited by-同舟云学术

Investigating the mechanotransduction of transient shear stress mediated by Piezo1 ion channel using a 3D printed dynamic gravity pump

Published:2022 Issue:2 Volume:22 Page:262-271
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Concilia Gianmarco¹^ORCID,Lai Austin²,Thurgood Peter¹^ORCID,Pirogova Elena¹,Baratchi Sara²^ORCID,Khoshmanesh Khashayar¹^ORCID

Affiliation:

1. School of Engineering, RMIT University, Melbourne, Victoria, Australia

2. School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia

Abstract

This work describes a 3D printed dynamic gravity pump for studying the response of mechanoresponsive cells expressing Piezo1 ion channels under transient flows.

Funder

National Health and Medical Research Council

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D1LC00927C

Reference63 articles.

1. Mechanically Activated Ion Channels

2. Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

3. Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

4. Adaptable pulsatile flow generated from stem cell-derived cardiomyocytes using quantitative imaging-based signal transduction

5. Force Sensing by Piezo Channels in Cardiovascular Health and Disease

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2. Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix;ACS APPL MATER INTER;2022

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