Planar organization of airway epithelial cell morphology using hydrogel grooves during ciliogenesis fails to induce ciliary alignment-Reference-Cited by-同舟云学术

Planar organization of airway epithelial cell morphology using hydrogel grooves during ciliogenesis fails to induce ciliary alignment

Published:2022 Issue:2 Volume:10 Page:396-409
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Varma Ratna¹²,Poon James¹²,Liao Zhongfa³,Aitchison J. Stewart³,Waddell Thomas K.¹²^ORCID,Karoubi Golnaz²⁴⁵,McGuigan Alison P.¹⁶^ORCID

Affiliation:

1. Institute of Biomedical Engineering (BME), University of Toronto, 164 College St, Toronto, ON, M5S 3G9, Canada

2. Latner Thoracic Surgery Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto General Hospital, University of Toronto, 101 College St, Toronto, ON, M5G 0A3, Canada

3. Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Rd, Toronto, ON M5S 3G8, Canada

4. Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Circle, Toronto, ON, M5S 3G8, Canada

5. Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada

6. Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St, Toronto, ON, M5S 3E5, Canada

Abstract

Here we align airway epithelial cells on hydrogel grooves and induce apical-basal polarization and cilia formation. Neither initial alignment, nor maintained alignment on the grooves induced polarized cilia alignment in the epithelial sheet.

Funder

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01327K

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