Students in general chemistry were partitioned into three groups by cluster analysis of six affective characteristics (emotional satisfaction, intellectual accessibility, chemistry self-concept, math self-concept, self-efficacy, and test anxiety). The at-home study strategies for exam preparation and in-class learning strategies differed among the three groups. Students in the high group (strongly positive affective characteristics) were more autonomous learners, reporting they understood the notes they took in lecture more frequently than the group with low (more negative) affective characteristics. The high group also relied less on tutors and teaching assistants for help when preparing for exams. Participating in explanatory behavior (with self or other students) was correlated positively with stronger exam performance, whereas rapt attention or assiduous note-taking in lecture was negatively correlated. The high and low affective groups were indistinct in their reports of amount of quality time spent studying, but did differ in their approach to using a practice exam as a resource.