Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces-Reference-Cited by-同舟云学术

Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces

Published:2024 Issue:20 Volume:12 Page:4935-4944
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Oh Min Jun¹²^ORCID,Kim Jae-Hyun¹^ORCID,Kim Jaekyoung¹,Lee Sunghee¹²^ORCID,Xiang Zhenting²^ORCID,Liu Yuan²^ORCID,Koo Hyun²³^ORCID,Lee Daeyeon¹³^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

2. Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

3. Center for Innovation & Precision Dentistry, School of Dental Medicine and School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Abstract

This study introduces dendritic microparticles from PLGA and PLGA-b-PEG for oral antifungal delivery. They adhere to oral surfaces, offer sustained release, and prevent biofilms, while being biodegradable, promising for treating oral infections.

Funder

National Institute of Dental and Craniofacial Research

Ministry of Education

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00134F

Reference28 articles.

1. The oral microbiota: dynamic communities and host interactions

2. pH-Mediated Potentiation of Aminoglycosides Kills Bacterial Persisters and Eradicates In Vivo Biofilms

3. Tolerance and resistance of microbial biofilms

4. Targeting microbial biofilms: current and prospective therapeutic strategies

5. Mechanical properties of human dental enamel on the nanometre scale