Design, synthesis and application in biological imaging of a novel red fluorescent dye based on a rhodanine derivative

Author:

Li Zijing12345,Huang Bin67845ORCID,Wang Yuan91011125,Yuan Wenbo12345,Wu Yijing12345,Yu Ruitao12345,Xing Guichuan13141516ORCID,Zou Taotao91011125ORCID,Tao Youtian12345ORCID

Affiliation:

1. Key Laboratory of Flexible Electronics

2. Institute of Advanced Materials

3. Nanjing Tech University

4. Nanjing

5. P. R. China

6. College of Life Sciences and Chemistry

7. Jiangsu Key Laboratory of Biofunctional Molecule

8. Jiangsu Second Normal University

9. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery

10. School of Pharmaceutical Sciences

11. Sun Yat-Sen University

12. Guangzhou

13. Institute of Applied Physics and Materials Engineering

14. University of Macau

15. Macao SAR 999078

16. China

Abstract

2RDNTPA can be applied in fluorescence imaging of living cancer cells (HepG2) with red emission of 620 nm and negligible cytotoxicity with a half maximal inhibitory concentration much more than 100 μM.

Funder

Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Natural Science Foundation of Jiangsu Province

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Universidade de Macau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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