Synthesis and biological evaluation of d-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of d-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease

Published:2016 Issue:2 Volume:7 Page:365-370
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Wang Jiajia¹²³⁴,Wang Xiaomin¹²³⁴,Zhao Yunyan¹²³⁴,Ma Xiaoyao¹²³⁴,Wan Yue¹²³⁴,Chen Zhongwei¹²³⁴,Chen Hao¹²³⁴,Gan Hao⁵⁴,Li Jing¹²³⁴,Li Lei⁶⁷⁸⁹,Wang Peng George¹²³⁴⁶,Zhao Wei¹²³⁴

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology

2. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research

3. Nankai University

4. PR China

5. Tianjin Chase Sun Pharmaceutical Co. LTD

6. The Department of Chemistry

7. Georgia State University

8. Atlanta

9. USA

Abstract

38 was an efficient pharmacological chaperone for GCase-related cell line N370S, which can effectively promote the activity of the mutant protein by 1.93-fold at 12.5 μM.

Funder

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00501A

Reference37 articles.

1. Gaucher disease: pathological mechanisms and modern management

2. The cell biology of lysosomal storage disorders

3. 1 Gaucher's disease: past, present and future

4. The molecular basis of lysosomal storage diseases and their treatment

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unexpected One‐Pot Formation of Lactam Oximes from Amino‐Hydroxamic Esters;European Journal of Organic Chemistry;2022-05-31

2. Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC–MS: A potential agent for promoting tumor-targeted drug delivery;Journal of Pharmaceutical and Biomedical Analysis;2020-06

3. Bicyclic 1-Azafagomine Derivatives: Synthesis and Glycosidase Inhibitory Testing;Synthesis;2019-08-14

4. Total synthesis of N-butyl-1-deoxynojirimycin;Journal of Carbohydrate Chemistry;2016-11-21

5. First total synthesis of (+)-broussonetine W: glycosidase inhibition of natural product & analogs;Organic & Biomolecular Chemistry;2016